{"id":8315,"date":"2024-08-27T16:47:24","date_gmt":"2024-08-27T16:47:24","guid":{"rendered":"https:\/\/chm.atu.edu.iq\/?p=8315"},"modified":"2024-08-27T16:47:24","modified_gmt":"2024-08-27T16:47:24","slug":"%d8%a3%d8%b7%d8%b1%d9%88%d8%ad%d8%a9-%d8%af%d9%83%d8%aa%d9%88%d8%b1%d8%a7%d9%87-%d9%81%d9%8a-%d8%ac%d8%a7%d9%85%d8%b9%d8%a9-%d8%a7%d9%84%d9%81%d8%b1%d8%a7%d8%aa-%d8%a7%d9%84%d8%a7%d9%88%d8%b3%d8%b7-2","status":"publish","type":"post","link":"https:\/\/chm.atu.edu.iq\/?p=8315","title":{"rendered":"\u0623\u0637\u0631\u0648\u062d\u0629 \u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0641\u064a \u062c\u0627\u0645\u0639\u0629 \u0627\u0644\u0641\u0631\u0627\u062a \u0627\u0644\u0627\u0648\u0633\u0637 \u0627\u0644\u062a\u0642\u0646\u064a\u0629 \u0628\u0639\u0646\u0648\u0627\u0646 (\u062a\u0642\u062f\u064a\u0631 CD20 , CXC-10 , IL-4, IL-17 \u0648microRNA-762 \u0643\u0645\u0624\u0634\u0631\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u0644\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u064a\u0646 \u0641\u064a \u0645\u0631\u0636\u0649 \u062a\u0636\u062e\u0645 \u0627\u0644\u063a\u062f\u0647 \u0627\u0644\u062f\u0631\u0642\u064a\u0629)"},"content":{"rendered":"\n

\u0628\u062d\u062b\u062a \u0623\u0637\u0631\u0648\u062d\u0629 \u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0641\u064a \u0643\u0644\u064a\u0629 \u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u0629 \u0648\u0627\u0644\u0637\u0628\u064a\u0629 \/\u0643\u0648\u0641\u0629 \u0627\u0644\u062a\u064a \u0642\u062f\u0645\u062a\u0647\u0627 \u0627\u0644\u0628\u0627\u062d\u062b\u0629 (\u0647\u0627\u0644\u0629 \u0633\u0644\u064a\u0645 \u062c\u0645\u0639\u0647)\u0647\u062f\u0641\u062a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0647 (150) \u0641\u0631\u062f\u0627\u064b \u0645\u0646 \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u062c\u0646\u0633 \u0648\u0627\u0644\u0641\u0626\u0627\u062a \u0627\u0644\u0639\u0645\u0631\u064a\u0629. \u062a\u0643\u0648\u0646\u062a \u0645\u0646 \u062b\u0644\u0627\u062b \u0645\u062c\u0645\u0648\u0639\u0627\u062a\u060c \u0636\u0645\u062a \u0643\u0644 \u0645\u0646\u0647\u0627 50 \u0645\u0634\u0627\u0631\u0643\u0627\u060c \u0648\u0647\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0645\u0631\u0636 \u062c\u0631\u064a\u0641\u0632 \u0645\u0639 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u064a\u0646 (GO)\u060c \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0644\u0645\u0631\u0636 \u062c\u0631\u064a\u0641\u0632 \u062f\u0648\u0646 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u064a\u0646 (GD) \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0636\u0645\u062a 50 \u0627\u0634\u062e\u0627\u0635 \u0627\u0635\u062d\u0627\u0621.<\/strong><\/p>\n\n\n\n

\u0648\u0642\u062f \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646 \u0645\u0631\u0636 GO \u0643\u0627\u0646 \u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u0627 \u0641\u064a 31-40 \u0633\u0646\u0629 (38.0\u066a). \u063a\u0627\u0644\u0628\u064a\u0629 \u0645\u0631\u0636\u0649 GO \u0643\u0627\u0646\u0648\u0627 \u0645\u0646 \u0627\u0644\u0625\u0646\u0627\u062b (76%) \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0630\u0643\u0648\u0631 (24%). \u0648\u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u0642\u064a\u0645\u0629 TRAB \u0623\u0639\u0644\u0649 \u0628\u0643\u062b\u064a\u0631 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 GO \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0643\u0644 \u0645\u0646 GD \u0648\u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629\u060c )8.32\u060c 5.98 \u0648 0.66 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a .<\/strong><\/p>\n\n\n\n

\u0623\u0638\u0647\u0631\u062a \u062a\u0642\u0646\u064a\u0629 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u062f\u0641\u0642 \u0627\u0644\u062e\u0644\u0648\u064a \u0623\u0646 \u0646\u0633\u0628\u0629 (CD20%) \u0641\u064a GO \u0623\u0639\u0644\u0649 \u0628\u0643\u062b\u064a\u0631 \u0645\u0646 \u0645\u0627 \u0641\u064a GD \u0648\u0627\u0644\u062a\u062d\u0643\u0645 (4.6\u00b1 2.4% VS 3.3\u00b11.7 % \u0648 1.6\u00b11.1%\u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a).<\/strong><\/p>\n\n\n\n

\u0623\u0638\u0647\u0631\u062a \u062a\u0642\u0646\u064a\u0629 ELISA \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 GO \u0643\u0627\u0646\u062a \u0623\u0639\u0644\u0649 \u0628\u0643\u062b\u064a\u0631 \u0645\u0646 \u0645\u0627 \u0641\u064a GD \u0648\u0627\u0644\u0633\u064a\u0637\u0631\u0629\u060c \u062d\u064a\u062b \u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u062a\u0631\u0643\u064a\u0632 \u0645\u0633\u062a\u0648\u0649 CXC-10 (173.5\u00b146 \u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645\/\u0644\u062a\u0631) \u0645\u0642\u0627\u0628\u0644 ( 153.5\u00b125.6\u0628\u064a\u0643\u0648 \u063a\u0631\u0627\u0645 \/ \u0644\u062a\u0631 ) \u0648 (80.3\u00b1 26.1\u0628\u064a\u0643\u0648 \u063a\u0631\u0627\u0645 \/\u0644\u062a\u0631)\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a . IL-4 ( 462.8 \u00b1 153.4 \u0628\u064a\u0643\u0648 \u063a\u0631\u0627\u0645 \/\u0644\u062a\u0631) \u0645\u0642\u0627\u0628\u0644 402.4\u00b188.\u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645 \/\u0644\u062a\u0631) \u0648 (218.4\u00b154.1 \u0646\u0627\u0646\u0648\u063a\u0631\u0627\u0645\/\u0644\u062a\u0631 ) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.\u0648\u0623\u062e\u064a\u0631\u064b\u0627\u060c \u0643\u0627\u0646 \u0645\u0633\u062a\u0648\u0649IL-17 402.6\u00b1104.7)\u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645\/\u0644\u062a\u0631) \u0645\u0642\u0627\u0628\u0644 ) 237.2\u00b183.7 \u0628\u064a\u0643\u0648 \u063a\u0631\u0627\u0645\/\u0644\u062a\u0631) \u0648 190.8 )\u00b133.7 \u0628\u064a\u0643\u0648\u063a\u0631\u0627\u0645\/\u0644\u062a\u0631) \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u064a\u0638\u0647\u0631 \u0645\u0646\u062d\u0646\u0649 (ROC )\u060c, AUC (0.80 ) CXC-10 cutoff (129 )\u060c \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 (96 %\u060c) \u0627\u0644\u0646\u0648\u0639\u064a\u0647 (.(54% IL-4 ( cutoff( 303.5 ) ,AUC ( 0 .78 , \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0647 ) 98% ) , \u0627\u0644\u0646\u0648\u0639\u064a\u0647 ( 49%). \u0627\u062e\u0631\u0627 IL-17 AUC(0.93) ,cutoff (263.5 ), \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0647 (86.0%) , \u0627\u0644\u0646\u0648\u0639\u064a\u0647 (0.90%).<\/strong><\/p>\n\n\n\n

\u0643\u0627\u0646 \u062a\u0639\u0628\u064a\u0631 miR-762 \u0627\u0643\u0628\u0631 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638 (P\u02c20.01) \u0641\u064a \u0645\u0631\u0636\u0649 GO( 11.2 Fold change=) \u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0647 \u0645\u0639 \u0645\u062c\u0645\u0648\u0639\u062a\u064a GD \u0648\u0627\u0644\u0627\u0635\u062d\u0627\u0621 ( 7.4 fold change= ) \u0648( 3.0 fold chang= ) \u0628\u0627\u0644\u062a\u0648\u0627\u0644\u064a .<\/strong><\/p>\n\n\n\n

\u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0645\u0639\u0646\u0648\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0647 \u0645\u0631\u0636\u0649 GO \u0628\u064a\u0646 miR-762 \u0648\u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646. \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u064a\u0646 MiR-762 \u0648CXC-10 (R = 0.469, P = 0.05). . \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0627\u0644\u062b\u0627\u0646\u064a \u0628\u064a\u0646 MiR-762 \u0648 IL-4 (R = 0.565, P = 0.01) \u0648\u0627\u0644\u0623\u062e\u064a\u0631 \u0628\u064a\u0646 MiR-762 \u0648IL17 ( R = 0.689, P = 0.01 ).<\/strong><\/p>\n\n\n\n

\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0647\u0646\u0627\u0643 \u062b\u0644\u0627\u062b\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u0628\u064a\u0646 \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629. \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u064a\u0646 CD-20 \u0648 IL-4 (r =.522, p 0.05) . \u0648\u0627\u0644\u062b\u0627\u0646\u064a \u064a\u0642\u0639 \u0628\u064a\u0646 CXC-10 \u0648 IL-4 (r =.314, P = 0.026). \u0648\u0623\u062e\u064a\u0631\u064b\u0627\u060c \u0647\u0646\u0627\u0643 \u0627\u0631\u062a\u0628\u0627\u0637 \u062b\u0627\u0644\u062b \u0628\u064a\u0646 CXC-10 \u0648IL-17 ( (r =.437, p = 0.001 .<\/strong><\/p>\n\n\n\n

\u0648\u0642\u062f \u0623\u062f\u0649 \u0647\u0630\u0627 \u0627\u0644\u0627\u0639\u062a\u0631\u0627\u0641 \u0625\u0644\u0649 \u0627\u0643\u062a\u0634\u0627\u0641\u0627\u062a \u0645\u0647\u0645\u0629 \u062d\u0648\u0644 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u0645\u0631\u0636 \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0648\u0641\u0631 \u0627\u062a\u062c\u0627\u0647\u064b\u0627 \u062c\u062f\u064a\u062f\u064b\u0627 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u0645\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0648\u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0628\u064a\u0646 \u0645\u0631\u0636 \u062c\u0631\u064a\u0641\u0632 \u0645\u0639 \u0648\u0628\u062f\u0648\u0646 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0639\u064a\u0646.<\/strong><\/p>\n\n\n\n

\u0634\u0639\u0628\u0629 \u0627\u0644\u0627\u0639\u0644\u0627\u0645 \u0648\u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0627\u0644\u062d\u0643\u0648\u0645\u064a<\/strong><\/p>\n\n\n\n

\u0643\u0644\u064a\u0629 \u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u0629 \u0648\u0627\u0644\u0637\u0628\u064a\u0629 \/\u0643\u0648\u0641\u0629<\/strong><\/p>\n\n\n\n

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<\/p>\n\n\n\n

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